First approved in 2007, Tasigna (nilotinib), is a prescription medication used to treat chronic myeloid leukaemia (CML). Tasigna is part of a class of drugs known as tyrosine kinase inhibitors (TKIs). Other TKI drugs include Gleevec (imatinib), also made by Novartis, and Sprycel (dasatinib), made by Bristol-Myers Squibb.
These drugs help treat leukemia by blocking the protein tyrosine kinases—a protein that stimulates the growth of cancer cells. In blocking this protein, TKI drugs like Tasigna help stop leukemia from spreading. Tasigna is prescribed as a twice daily drug and is taken orally in capsule form.
WHAT IS THE PROBLEM WITH TASIGNA?
Injured patients and their families are now filing lawsuits against Tasigna manufacturer Novartis, on the grounds that the company failed to warn of the drug’s cardiovascular risks. Studies have allegedly linked the drug to serious cardiovascular side effects like Long QT syndrome, a condition involving irregular heartbeats, and atherosclerosis, a disease that causes plaque to build up in the arteries.
The FDA issued a black box warning (the highest warning they can issue) for Tasigna’s link to QT interval prolongation and sudden death.
WHAT ARE THE TASIGNA CARDIOVASCULAR SIDE EFFECTS?
To date, approximately 15,500 Tasigna related adverse events and 2,786 deaths have allegedly been reported to the FDA to date. These include serious Tasigna side effects including cardiovascular side effects, like Long QT syndrome, myocardial ischemia, and atherosclerosis.
Tasigna has one black box warning—the highest warning the FDA can issue—for Long QT syndrome, or QT interval prolongation, and sudden death. It is a condition that affects heart rhythm, resulting in fast, irregular heartbeats. If left untreated, it can result in fainting, seizures, and sudden death.
Tasigna may also been linked to myocardial ischemia, a condition involving reduced blood flow to the heart, causing a decreased amount of oxygen sent to the heart. Myocardial ischemia is usually caused by a blockage of the coronary arteries.
Recent lawsuits have also been filed over the drug’s alleged connection to atherosclerosis, a disease that causes fatty deposits to build up and eventually clog arteries. This serious condition gradually reduces blood flow and oxygen to cells.
Atherosclerosis is currently the leading cause of death in the developed world. It may eventually cause the following complications:
ARE THERE STUDIES LINKING TASIGNA TO CARDIOVASCULAR EVENTS?
Two recent studies have connected Tasigna with cardiovascular events:
The FDA’s adverse event reporting database has received more than 100 reports of Tasigna-related myocardial ischemia diagnoses. Myocardial ischemia is a condition that is usually caused by a blockage of the coronary arteries. It results in reduced blood flow to the heart, decreasing the amount of oxygen to the heart. In an FDA post-market review, 5.8% of patients taking Tasigna allegedly suffered ischemic heart.
Atherosclerosis is a disease that causes fatty deposits to build up and eventually clog arteries. This serious condition gradually reduces blood flow and oxygen to cells. Atherosclerosis may eventually cause coronary artery disease, peripheral arterial disease, blood clots, heart attacks, or strokes. It’s currently the leading cause of death in the developed world.
Since 2013, Tasigna products sold in Canada come with a warning of the drug’s connection to atherosclerosis. This label change came after Canadian health officials warned that 277 cases of atherosclerosis were allegedly reported worldwide. Lawsuits allege that Novartis never warned of the risk of atherosclerosis in the U.S. though, despite these reports.
Other serious Tasigna side effects noticed by the FDA that may be linked to Tasigna include low blood cell counts; decreased blood flow to the heart, lungs, or brain; pancreatitis; and Tumor Lysis Syndrome, a condition that can occur when cancer cells are broken down quickly, resulting in kidney failure or an abnormal heartbeat.
Lawsuits have been filed some patients against Novartis. who took Tasigna and subsequently suffered a heart or circulation problem. The lawsuits allege Novartis failed to properly warn of these side effe
WHAT ARE SOME OF THE TASIGNA SIDE EFFECTS?
Novartis warns of the following Tasigna side effects:
HOW DO I KNOW IF I AM ELIGIBLE FOR A TASIGNA LAWSUIT?
If you or a loved one took Tasigna and suffered heart or circulation problems (including complications like blocked arteries, heart attacks, or strokes), you could be eligible for a Tasigna lawsuit and possible entitled to substantial compensation. Call Tasigna lawyer Timothy L. Miles today for a free case evaluation to see if you are eligible for a Tasigna lawsuit.
CALL A TASIGNA LAWYER TO SEE IF YOU ARE ELIGIBLE FOR A TASIGNA LAWSUIT?
If you or a loved one took Tasigna and suffered heart or circulation problems (including complications like blocked arteries, heart attacks, or strokes), you could be eligible for a Tasigna Lawsuit. If you suffered Tasigna side effects, including Tasigna cardiovascular side effects, call Tasigna lawyer Timothy L. Miles today for a free case evaluation and see if you qualify for a Tasigna lawsuit.
TIMOTHY L. MILES, ESQ.
Timothy L. Miles is a nationally recognized shareholder and consumer rights attorney raised in Nashville, Tennessee. Mr. Miles was recently selected by Martindale-Hubbell® and ALM as a 2023 Top Ranked Lawyer, 2023 Top Rated Litigator. and a 2023 Elite Lawyer of the South. Mr. Miles also maintains the AV Preeminent Rating by Martindale-Hubbell®, their highest rating for both legal ability and ethics. Mr. Miles is a member of the prestigious Top 100 Civil Plaintiff Trial Lawyers: The National Trial Lawyers Association, a superb rated attorney by Avvo, a recipient of the Lifetime Achievement Award by Premier Lawyers of America (2019) and recognized as a Distinguished Lawyer, Recognizing Excellence in Securities Law, by Lawyers of Distinction (2019). Mr. Miles has published over sixty articles on various issues of the law, including class actions, whistleblower cases, products liability, and more.
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